Abstract: Objective To summarize the method of establishing traumatic hemorrhage model in rabbit. Method By consulting the domestic and foreign literatures on rabbit traumatic hemorrhage model, selection of anesthetics and dosage, modeling process, and evaluation indicators of hemostatic effects were analyzed. Result The common rabbit traumatic hemorrhage models include auricular arteriovenous traumatic models, surface skin traumatic models, femoral artery traumatic models, and Visceral organs models such as liver and spleen. When determining the anesthetics and doses, types of hemorrhage model, operation time and medicinal properties should be comprehensively considered. When considering model establishment process and evaluation indicator, We can improve it on the basis of basic operation procedures according to concrete conditions. Conclusion The standard method of establishing rabbit traumatic hemorrhage model plays a key role in the scientific evaluation of the hemostatic materials. This reviewr provides a reference for the establishment of rabbit traumatic hemorrhage model and the determination of evaluation indicator.

Key words: rabbit, traumatic, animal model

摘要： 目的 概述兔创伤性出血模型建立方法。 方法 通过查阅国内外文献,对兔创伤性出血模型建立过程中麻醉药物及剂量的选择、建模方法以及建模后止血效果评价指标等内容进行分析总结。 结果 常见的兔创伤性出血模型有耳缘动静脉创伤性出血模型、体表皮肤创伤性出血模型、股动脉创伤性出血模型和以肝、脾、肾为代表的内脏创伤性出血模型。 麻醉药物和剂量的选择应综合考虑建模类型、手术时长和药物特性等来确定,建模方法和评价指标在常规操作的基础上,可以根据止血药物的使用场景来调整。 结论 标准的兔创伤性出血模型建立方法对于止血药物或止血材料的止血性能的科学评价起着关键作用,本文为兔创伤性出血模型的建立方法及评价指标的确定提供参考。

关键词: 兔, 创伤, 动物模型